<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">alternative</journal-id><journal-title-group><journal-title xml:lang="ru">Альтернативная энергетика и экология (ISJAEE)</journal-title><trans-title-group xml:lang="en"><trans-title>Alternative Energy and Ecology (ISJAEE)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1608-8298</issn><publisher><publisher-name>Международный издательский дом научной периодики "Спейс</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15518/isjaee.2021.09.160-174</article-id><article-id custom-type="elpub" pub-id-type="custom">alternative-2112</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ИННОВАЦИОННЫЕ РЕШЕНИЯ, ТЕХНОЛОГИИ, УСТРОЙСТВА АЛЬТЕРНАТИВНОЙ ЭНЕРГЕТИКИ ДЛЯ КОМПЕНСАЦИИ НЕБЛАГОПРИЯТНЫХ ВОЗДЕЙСТВИЙ ОКРУЖАЮЩЕЙ СРЕДЫ НА ОРГАНИЗМЫ. НАНОТЕХНОЛОГИИ ДЛЯ АЛЬТЕРНАТИВНОЙ ЭНЕРГЕТИКИ, ЭКОЛОГИИ И МЕДИЦИНЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>INNOVATIVE SOLUTIONS, TECHNOLOGIES, ALTERNATIVE ENERGY DEVICES FOR COMPENSATION OF ADVERSE ENVIRONMENTAL IMPACT ON ORGANISMS. NANOTECHNOLOGY FOR ALTERNATIVE ENERGY, ECOLOGY AND MEDICINE</subject></subj-group></article-categories><title-group><article-title>Перспективы применения новых лекарственных препаратов на основе реструктурированного цинка в условиях изменения климата и экологии</article-title><trans-title-group xml:lang="en"><trans-title>Prospects for the use of new medical technologies based on restructured zinc in the conditions of climate change and ecology</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Соловьев</surname><given-names>Е. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Solovyov</surname><given-names>E. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Соловьев Евгений Михайлович, к.т.н., Гл. конструктор</p><p>Москва, 129327</p></bio><bio xml:lang="en"><p>Solovyov E. M., Ph/D., Major constructor</p><p>Moscow, 129327</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кириллов</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kirillov</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кириллов Давид Арчилович, кандидат медицинских наук</p><p>Москва, 129327</p></bio><bio xml:lang="en"><p>Kirillov D. A., PhD medicine</p><p>Moscow, 129327</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Спицын</surname><given-names>Б. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Spitsyn</surname><given-names>B. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Спицын Борис Владимирович, доктор химических наук, гл. научный сотрудник</p><p>119991, Москва ГСП-1, Ленинский проспект, 31</p></bio><bio xml:lang="en"><p>Spitsyn B. V., D. Sc chemistry Major Researcher</p><p>119991, Moscow GSP-1, Leninsky Prospekt, 31</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Киселев</surname><given-names>М. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Kiselev</surname><given-names>M. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Киселев Михаил Романович, к.х.н., ст. научный сотрудник</p><p>119991, Москва ГСП-1, Ленинский проспект, 31</p></bio><bio xml:lang="en"><p>Kiselev M. R., D Ph chemistry Senyor</p><p>119991, Moscow GSP-1, Leninsky Prospekt, 31</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Квачакидзе</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kvachakidze</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Квачакидзе Анатолий Валикович, специалист</p><p>Москва, 129327</p></bio><bio xml:lang="en"><p>Kvachakidze A.V., specialist</p><p>Moscow, 129327</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сорокин</surname><given-names>Б. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sorokin</surname><given-names>B. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сорокин Борис Альбертович, к.м.н., специалист</p><p>Москва, 129327</p></bio><bio xml:lang="en"><p>Sorokin B. A., D Ph medical, specialist</p><p>Moscow, 129327</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дрожжина</surname><given-names>Ю. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Drozhzhina</surname><given-names>Yu. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дрожжина Юлия Сергеевна, специалист</p><p>Москва, 129327</p></bio><bio xml:lang="en"><p>Drozhzhina Yu. S., specialist</p><p>Moscow, 129327</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ООО «СОЛМЕТ»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>OOO "SOLMET"</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Институт физической химии и электрохимии им. А.Н.Фрумкина Российской академии наук</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Frumkin Institute of Physical Chemistry and Electrochemistry of the Russian Academy of Sciences</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>02</day><month>04</month><year>2022</year></pub-date><volume>0</volume><issue>25-27</issue><fpage>160</fpage><lpage>174</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Международный издательский дом научной периодики "Спейс, 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Международный издательский дом научной периодики "Спейс</copyright-holder><copyright-holder xml:lang="en">Международный издательский дом научной периодики "Спейс</copyright-holder><license xlink:href="https://www.isjaee.com/jour/about/submissions#copyrightNotice" xlink:type="simple"><license-p>https://www.isjaee.com/jour/about/submissions#copyrightNotice</license-p></license></permissions><self-uri xlink:href="https://www.isjaee.com/jour/article/view/2112">https://www.isjaee.com/jour/article/view/2112</self-uri><abstract><p>Изменение экологии и климата сопряжено с напряжением механизмов адаптации организмов кменяющимся условиям среды обитания. Микроэлементы являются неотъемлемой частью обмена веществ и связаны с процессами жизнедеятельности биообъектов. Реструктурированный цинк открывает новые горизонты изучения и применения микроэлементов в биологии и медицине. Представлены результаты реструктурированного цинка, полученного в реакторе нового типа (Институт физической химии и электрохимии А.Н. Фрумкина). Путем длительного термодинамического воздействия на расплав металла, был получен химически чистый цинк, обладающий новой структурой и вследствие этого, новыми химическими и физическими свойствами. Чтобы оценить химическую активность цинка образцы подвергались окислению на термогравиметрическом анализаторе TGA Q500 InterTech Corporation в среде осушенного воздуха в динамическом режиме. Температурный диапазон измерений составлял 35-600 °C при скорости нагрева 10 °C/мин.</p></abstract><trans-abstract xml:lang="en"><p>Changes in ecology and climate are associated with the strain of the mechanisms of adaptation of organisms to changing environmental conditions. Trace elements are an integral part of the metabolism and are associated with the processes of vital activity of biological objects. Restructured zinc opens up new horizons for the study and application of trace elements in biology and medicine. The results of the restructured zinc obtained in a new type of reactor (A. N. Frumkin Institute). By prolonged thermodynamic action on the metal melt, chemically pure zinc was obtained, which has a new structure and, consequently, new chemical and physical properties. To assess the chemical activity of zinc, the samples were subjected to oxidation on a thermogravimetric analyzer TGA Q500 InterTech Corporation in a dehumidified air environment in a dynamic mode. The temperature range of measurements was 35-600 °C at a heating rate of 10 °C / min.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>реструктурированный цинк</kwd><kwd>расплав металла</kwd><kwd>ротор</kwd><kwd>скорость вращения</kwd><kwd>микроэлемент</kwd><kwd>функции цинка</kwd></kwd-group><kwd-group xml:lang="en"><kwd>restructured zinc</kwd><kwd>metal melts rotor</kwd><kwd>rotation speed</kwd><kwd>trace element</kwd><kwd>zinc functions</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Работа выполнена в инициативном порядке без специального финансирования, но при активном содействии и консультационном участии врачей Института им. Склифосовского</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">К физической модели образования вакансионных кластерных трубок и изменений свойств металлов при центробежном динамическом литье. Е.М. Соловьев, В. И. Новиков, Б. В. Спицын, М. Р., Киселев, Б. А. Сорокин, А. В. Квачакидзе (Журнал «Альтернативная энергетика и экология» https://doi.org/10.15518/isjaee.2016.15-18.096-103).</mixed-citation><mixed-citation xml:lang="en">K fizicheskoi modeli obrazovaniya vakansionnykh klasternykh trubok i izmenenii svoistv metallov pri tsentrobezhnom dinamicheskom lit'e. E.M. Solov'ev, V. I. Novikov, B. V. Spitsyn, M. R., Kiselev, B. A. Sorokin, A. V. Kvachakidze (Zhurnal «Al'ternativnaya ehnergetika i ehkologiYA» https://doi.org/10.15518/isjaee.2016.15-18.096-103).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Исследование вакансионной системы рестуктурированного цинка методом аннигиляции позитронов Е.М. Соловьев, Б.В. Спицын, Р.С. Лаптев, А.М. Лидер, Ю.С. Бордулев, А.А. Михайлов (Журнал технической физики 2018. том 88, вып. 6).</mixed-citation><mixed-citation xml:lang="en">Issledovanie vakansionnoi sistemy restukturirovannogo tsinka metodom annigilyatsii pozitronov E.M. Solov'ev, B.V. Spitsyn, R.S. Laptev, A.M. Lider, YU.S. Bordulev, A.A. Mikhailov (Zhurnal tekhnicheskoi fiziki 2018. tom 88, vyp. 6).</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Клиническое значение дефицита цинка для здоровья детей: новые возможности лечения и профилактики Оригинальная статья опубликована на сайте РМЖ (Русский медицинский журнал): https://www.rmj.ru/articles/pediatriya/Klinicheskoe_znachenie_deficita_cinka_dlya_zdorovyya_detey_novye_vozmoghnosti_lecheniya_i_profilaktiki/#ixzz6ytU2xFvl.</mixed-citation><mixed-citation xml:lang="en">Klinicheskoe znachenie defitsita tsinka dlya zdorov'ya detei: novye vozmozhnosti lecheniya i profilaktiki Original'naya stat'ya opublikovana na saite RMZH (Russkii meditsinskii zhurnal): https://www.rmj.ru/articles/pediatriya/Klinicheskoe_znachenie_deficita_cinka_dlya_zdorovyya_detey_novye_vozmoghnosti_lecheniya_i_profilaktiki/#ixzz6ytU2xFvl.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">National Institutes of Health: Vitamin K - Fact Sheet for Health Professionals. https://ods.od.nih.gov/factsheets/vita-minKHealthProfessional/urisimplehttps://ods.od.nih.gov/factsheets/vita-minK-HealthProfessional/ Accessed June 3, 2020.</mixed-citation><mixed-citation xml:lang="en">National Institutes of Health: Vitamin K - Fact Sheet for Health Professionals. https://ods.od.nih.gov/factsheets/vita-minKHealthProfessional/urisimplehttps://ods.od.nih.gov/factsheets/vita-minK-HealthProfessional/ Accessed June 3, 2020.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Радилов А. С. Экспериментальная оценка токсичности и опасности наноразмерных материалов - Нанотехнологии и наука 2009 №1 с 86-89). Глущенко Н.Н. Токсичность наночастиц цинка и его биологические свойства/ Н.Н. Глущенко, А.В. Скальный // Актуальные проблемы транспортной медицины. — 2010. —№3, (21). — С. 118–121.</mixed-citation><mixed-citation xml:lang="en">Radilov A. S. Ehksperimental'naya otsenka toksichnosti i opasnosti nanorazmernykh materialov - Nanotekhnologii i nauka 2009 №1 s 86-89). Glushchenko N.N. Toksichnost' nanochastits tsinka i ego biologicheskie svoistva/ N.N. Glushchenko, A.V. Skal'nyi // Aktual'nye problemy transportnoi meditsiny. — 2010. —№3, (21). — S. 118–121.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Maret W. Molecular aspects of human cellular zinc homeostasis: redox control of zinc potentials and zinc signals // Biometals. 2009; 22: 1: 149-157.</mixed-citation><mixed-citation xml:lang="en">Maret W. Molecular aspects of human cellular zinc homeostasis: redox control of zinc potentials and zinc signals // Biometals. 2009; 22: 1: 149-157.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">https://www.spandidos-publications.com /10.3892/ijmm.2020.4790 Zinc and SARS CoV 2: A molecular modeling study of Zn interactions with RNA dependent RNA polymerase and 3C like proteinase enzymes.</mixed-citation><mixed-citation xml:lang="en">https://www.spandidos-publications.com /10.3892/ijmm.2020.4790 Zinc and SARS CoV 2: A molecular modeling study of Zn interactions with RNA dependent RNA polymerase and 3C like proteinase enzymes.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Beyersmann D and Haase H: Functions of zinc in signaling, proliferation and differentiation of mammalian cells. Biometals. 14:331–341. 2001.</mixed-citation><mixed-citation xml:lang="en">Beyersmann D and Haase H: Functions of zinc in signaling, proliferation and differentiation of mammalian cells. Biometals. 14:331–341. 2001.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Marreiro D do N, Cruz KJ, Morais JB, Beserra JB, Severo JS and Soares de Oliveira AR: Zinc and oxidative stress: Current mechanisms. Antioxidants (Basel). 6:242017.</mixed-citation><mixed-citation xml:lang="en">Marreiro D do N, Cruz KJ, Morais JB, Beserra JB, Severo JS and Soares de Oliveira AR: Zinc and oxidative stress: Current mechanisms. Antioxidants (Basel). 6:242017.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Maywald M, Wessels I and Rink L: Zinc signals and immunity. Int J Mol Sci. 18:22222017.</mixed-citation><mixed-citation xml:lang="en">Maywald M, Wessels I and Rink L: Zinc signals and immunity. Int J Mol Sci. 18:22222017.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Miller BD and Welch RM: Food system strategies for preventing micronutrient malnutrition. Food Policy. Wolters Kluwer-Medknow Publications; pp. 115–128. 2013.</mixed-citation><mixed-citation xml:lang="en">Miller BD and Welch RM: Food system strategies for preventing micronutrient malnutrition. Food Policy. Wolters Kluwer-Medknow Publications; pp. 115–128. 2013.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Discovery of Human Zinc Deficiency: Its Impact on Human Health and Disease Ananda S. Prasad Author NotesAdvances in Nutrition, Volume 4, Issue 2, March 2013, Pages 176–190.</mixed-citation><mixed-citation xml:lang="en">Discovery of Human Zinc Deficiency: Its Impact on Human Health and Disease Ananda S. Prasad Author NotesAdvances in Nutrition, Volume 4, Issue 2, March 2013, Pages 176–190.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Dowd, P.S.; Kelleher, J.; Guillou, P.J. Tlymphocyte subsets and interleukin-2 production in zincdeficient rats. Br. J. Nutr. 1986, 55, 59–69.</mixed-citation><mixed-citation xml:lang="en">Dowd, P.S.; Kelleher, J.; Guillou, P.J. Tlymphocyte subsets and interleukin-2 production in zincdeficient rats. Br. J. Nutr. 1986, 55, 59–69.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Fernandes, G.; Nair, M.; Onoe, K.; Tanaka, T.; Floyd, R.; Good, R.A. Impairment of cell-mediated immunity functions by dietary zinc deficiency in mice. Proc. Natl. Acad. Sci. USA 1979, 76, 457–461.</mixed-citation><mixed-citation xml:lang="en">Fernandes, G.; Nair, M.; Onoe, K.; Tanaka, T.; Floyd, R.; Good, R.A. Impairment of cell-mediated immunity functions by dietary zinc deficiency in mice. Proc. Natl. Acad. Sci. USA 1979, 76, 457–461.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Nutrients 2018, 10, 199 14 of 19.</mixed-citation><mixed-citation xml:lang="en">Nutrients 2018, 10, 199 14 of 19.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Golden, M.H.; Jackson, A.A.; Golden, B.E. Effect of zinc on thymus of recently malnourished children. Lancet 1977, 2, 1057–1059.</mixed-citation><mixed-citation xml:lang="en">Golden, M.H.; Jackson, A.A.; Golden, B.E. Effect of zinc on thymus of recently malnourished children. Lancet 1977, 2, 1057–1059.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">DePasquale-Jardieu, P.; Fraker, P.J. The role of corticosterone in the loss in immune function in the zincdeficient A/J mouse. J. Nutr. 1979, 109, 1847–1855.</mixed-citation><mixed-citation xml:lang="en">DePasquale-Jardieu, P.; Fraker, P.J. The role of corticosterone in the loss in immune function in the zincdeficient A/J mouse. J. Nutr. 1979, 109, 1847–1855.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Aydemir, T.B.; Liuzzi, J.P.; McClellan, S.; Cousins, R.J. Zinc transporter ZIP8 (SLC39A8) and zinc influence IFN-γ expression in activated human T cells. J. Leukoc. Biol. 2009, 86, 337–348.</mixed-citation><mixed-citation xml:lang="en">Aydemir, T.B.; Liuzzi, J.P.; McClellan, S.; Cousins, R.J. Zinc transporter ZIP8 (SLC39A8) and zinc influence IFN-γ expression in activated human T cells. J. Leukoc. Biol. 2009, 86, 337–348.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Wessels, I.; Maywald, M.; Rink, L. Zinc as a gatekeeper of immune function. Nutrients 2017, 9, 1286.</mixed-citation><mixed-citation xml:lang="en">Wessels, I.; Maywald, M.; Rink, L. Zinc as a gatekeeper of immune function. Nutrients 2017, 9, 1286.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Синергидное применение цинка и витамина С для поддержки памяти, внимания и снижения риска развития заболеваний нервной системы Журнал: Журнал неврологии и психиатрии им. С.С. Корсакова. 2017;117(7): 112-1190.</mixed-citation><mixed-citation xml:lang="en">Sinergidnoe primenenie tsinka i vitamina S dlya podderzhki pamyati, vnimaniya i snizheniya riska razvitiya zabolevanii nervnoi sistemy Zhurnal: Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2017;117(7):112-1190.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Huskisson E., Maggini S., Ruf M. The influence of micronutrients on cognitive function and performance // J. Int. Med. Res. 2007, v. 35, p. 1–19.</mixed-citation><mixed-citation xml:lang="en">Huskisson E., Maggini S., Ruf M. The influence of micronutrients on cognitive function and performance // J. Int. Med. Res. 2007, v. 35, p. 1–19.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Maylor E. A., Simpson E. E., Secker D. L. et al. Effects of zinc supplementation on cognitive function in healthy middle-aged and older adults: the ZENITH study // Br. J. Nutr. 2006, p. 752–760.</mixed-citation><mixed-citation xml:lang="en">Maylor E. A., Simpson E. E., Secker D. L. et al. Effects of zinc supplementation on cognitive function in healthy middle-aged and older adults: the ZENITH study // Br. J. Nutr. 2006, p. 752–760.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Yoan Cherasse * and Yoshihiro Urade: Dietary Zinc Acts as a Sleep Modulator Int. J. Mol. Sci. 2017, 18, 2334.</mixed-citation><mixed-citation xml:lang="en">Yoan Cherasse * and Yoshihiro Urade: Dietary Zinc Acts as a Sleep Modulator Int. J. Mol. Sci. 2017, 18, 2334.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Tamano H., Koike Y., Nakada H. et al. Signifi cance of synaptic Zn2+ signaling in zincergic and non zincergic synapses in the hippocampus in cognition // J. Trace Elm. Med. Biol. 2016 Vol. 38 P. 93–98.</mixed-citation><mixed-citation xml:lang="en">Tamano H., Koike Y., Nakada H. et al. Signifi cance of synaptic Zn2+ signaling in zincergic and non zincergic synapses in the hippocampus in cognition // J. Trace Elm. Med. Biol. 2016 Vol. 38 P. 93–98.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Hie M., Tsukamoto I. Administration of zinc inhibits osteoclastogenesis through the suppression of RANK expression in bone // Eur. J.Pharmacol. 2011 Vol. 668, N1. Р. 140–146.</mixed-citation><mixed-citation xml:lang="en">Hie M., Tsukamoto I. Administration of zinc inhibits osteoclastogenesis through the suppression of RANK expression in bone // Eur. J.Pharmacol. 2011 Vol. 668, N1. R. 140–146.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Журавлева Е.А., Каменская Е.Н., Бульина Е.А. и соавт. Роль цинка и меди в микронутриентном статусе новорожденного // Экология человека. 2007 № 11 С. 23–28.</mixed-citation><mixed-citation xml:lang="en">Zhuravleva E.A., Kamenskaya E.N., Bul'ina E.A. i soavt. Rol' tsinka i medi v mikronutrientnom statuse novorozhdennogo // Ehkologiya cheloveka. 2007 № 11 S. 23–28.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Williams R.J. Zinc in evolution // J. Inorg. Biochem. 2012 Vol. 111 P. 104–109.</mixed-citation><mixed-citation xml:lang="en">Williams R.J. Zinc in evolution // J. Inorg. Biochem. 2012 Vol. 111 P. 104–109.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Журавлева Е.А., Каменская Е.Н., Бульина Е.А. и соавт. Роль цинка и меди в микронутриентном статусе новорожденного // Экология человека. 2007 № 11 С. 23–28.</mixed-citation><mixed-citation xml:lang="en">Zhuravleva E.A., Kamenskaya E.N., Bul'ina E.A. i soavt. Rol' tsinka i medi v mikronutrientnom statuse novorozhdennogo // Ehkologiya cheloveka. 2007 № 11 S. 23–28.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Синергидное применение цинка и витамина С для поддержки памяти, внимания и снижения риска развития заболеваний нервной системы Журнал: Журнал неврологии и психиатрии им. С.С. Корсакова. 2017;117(7): 112-119.</mixed-citation><mixed-citation xml:lang="en">Sinergidnoe primenenie tsinka i vitamina S dlya podderzhki pamyati, vnimaniya i snizheniya riska razvitiya zabolevanii nervnoi sistemy Zhurnal: Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2017;117(7):112-119.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Torshin I.Yu. Bioinformatics in the post-genomic era: sensing the change from molecular genetics to personalized medicine. Nova Biomedical Books, NY, USA, 2009, In «Bioinformatics in the Post-Genomic Era» series, ISBN: 978-1-60692-217-0.</mixed-citation><mixed-citation xml:lang="en">Torshin I.Yu. Bioinformatics in the post-genomic era: sensing the change from molecular genetics to personalized medicine. Nova Biomedical Books, NY, USA, 2009, In «Bioinformatics in the Post-Genomic Era» series, ISBN: 978-1-60692-217-0. Iz Trudnyi patsient 2010 tsink i zhelezo.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Шейбак В.М. Синтез и секреция инсулина: роль катионов цинка// Журнал Гродненского государственного медицинского университета. 2015 № 1 С. 5–8.</mixed-citation><mixed-citation xml:lang="en">Sheibak V.M. Sintez i sekretsiya insulina: rol' kationov tsinka// Zhurnal Grodnenskogo gosudarstvennogo meditsinskogo universiteta. 2015 № 1 S. 5–8.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Zinc and SARS-CoV-2: A molecular modeling study of Zn interactions with RNA-dependent RNA-polymerase and 3C-like proteinase enzymes. Ali Pormohammad, Nadia K. Monych, and Raymond J. Turner Int J Mol Med. 2021 Jan; 47(1): 326–334.</mixed-citation><mixed-citation xml:lang="en">Zinc and SARS CoV 2: A molecular modeling study of Zn interactions with RNA dependent RNA polymerase and 3C like proteinase enzymes. Ali Pormohammad, Nadia K. Monych, and Raymond J. Turner Int J Mol Med. 2021 Jan; 47(1): 326–334.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Read SA, Obeid S, Ahlenstiel C, Ahlenstiel G. The role of zinc in antiviral immunity. Adv Nutr. 2019;10:696–710. doi: 10.1093/advances/nmz013. [PMC free article] [PubMed] [CrossRef] [Google Scholar].</mixed-citation><mixed-citation xml:lang="en">Read SA, Obeid S, Ahlenstiel C, Ahlenstiel G. The role of zinc in antiviral immunity. Adv Nutr. 2019;10:696–710. doi: 10.1093/advances/nmz013. [PMC free article] [PubMed] [CrossRef] [Google Scholar].</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Korant BD, Butterworth BE. Inhibition by zinc of rhinovirus protein cleavage: Interaction of zinc with capsid polypeptides. J Virol. 1976; 18:298–306. doi: 10.1128/JVI.18.1.298-306.1976. [PMC free article][PubMed] [CrossRef] [Google Scholar].</mixed-citation><mixed-citation xml:lang="en">Korant BD, Butterworth BE. Inhibition by zinc of rhinovirus protein cleavage: Interaction of zinc with capsid polypeptides. J Virol. 1976; 18:298–306. doi: 10.1128/JVI.18.1.298-306.1976. [PMC free article][PubMed] [CrossRef] [Google Scholar].</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Kaushik N, Subramani C, Anang S, Muthumohan R, Shalimar, Nayak B, Ranjith-Kumar CT, Surjit M. Zinc salts block hepatitis E virus replication by inhibiting the activity of viral RNA-dependent RNA polymerase. J Virol. 2017; 91:e00754–e00717. doi: 10.1128/JVI.00754-17. [PMC free article] [PubMed] [CrossRef] [Google Scholar].</mixed-citation><mixed-citation xml:lang="en">Kaushik N, Subramani C, Anang S, Muthumohan R, Shalimar, Nayak B, Ranjith-Kumar CT, Surjit M. Zinc salts block hepatitis E virus replication by inhibiting the activity of viral RNA-dependent RNA polymerase. J Virol. 2017; 91:e00754–e00717. doi: 10.1128/JVI.00754-17. [PMC free article] [PubMed] [CrossRef] [Google Scholar].</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Korant BD, Kauer JC, Butterworth BE. Zinc ions inhibit replication of rhinoviruses. Nature. 1974; 248:588–590. doi: 10.1038/248588a0. [PubMed] [CrossRef] [Google Scholar].</mixed-citation><mixed-citation xml:lang="en">Korant BD, Kauer JC, Butterworth BE. Zinc ions inhibit replication of rhinoviruses. Nature. 1974; 248:588–590. doi: 10.1038/248588a0. [PubMed] [CrossRef] [Google Scholar].</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">te Velthuis AJ, van den Worml SH, Sims AC, Baric RS, Snijder EJ, van Hemert MJ. Zn2+ inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture. PLoS Pathog. 2010;6:e1001176. doi: 10.1371/journal.ppat.1001176.[PMC free article] [PubMed] [CrossRef] [Google Scholar].</mixed-citation><mixed-citation xml:lang="en">te Velthuis AJ, van den Worml SH, Sims AC, Baric RS, Snijder EJ, van Hemert MJ. Zn2+ inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture. PLoS Pathog. 2010;6:e1001176. doi: 10.1371/journal.ppat.1001176.[PMC free article] [PubMed] [CrossRef] [Google Scholar].</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Hsu JTA, Kuo CJ, Hsieh HP, Wang YC, Huang KK, Lin CPC, Huang PF, Chen X, Liang PH. Evaluation of metal-conjugated compounds as inhibitors of 3CL protease of SARS-CoV. FEBS Lett. 2004;574:116–120.</mixed-citation><mixed-citation xml:lang="en">Hsu JTA, Kuo CJ, Hsieh HP, Wang YC, Huang KK, Lin CPC, Huang PF, Chen X, Liang PH. Evaluation of metal-conjugated compounds as inhibitors of 3CL protease of SARS-CoV. FEBS Lett. 2004;574:116–120. doi: 10.1016/j.febslet.2004.08.015. [PMC free article] [PubMed] [CrossRef] [Google Scholar].</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">doi: 10.1016/j.febslet.2004.08.015. [PMC free article] [PubMed] [CrossRef] [</mixed-citation><mixed-citation xml:lang="en">Lee CC, Kuo CJ, Hsu MF, Liang PH, Fang JM, Shie JJ, Wang AH. Structural basis of mercury- and zinc-conjugated complexes as SARS-CoV 3C-like protease inhibitors. FEBS Lett. 2007;581:5454–5458. doi: 10.1016/j.febslet.2007.10.048. [PMC free article] [PubMed] [CrossRef] [Google Scholar].</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Lee CC, Kuo CJ, Hsu MF, Liang PH, Fang JM, Shie JJ, Wang AH. Structural basis of mercury- and zinc-conjugated complexes as SARS-CoV 3C-like protease inhibitors. FEBS Lett. 2007;581:5454–5458. doi: 10.1016/j.febslet.2007.10.048. [PMC free article] [PubMed] [CrossRef] [Google Scholar].</mixed-citation><mixed-citation xml:lang="en">Krenn BM, Gaudernak E, Holzer B, Lanke K, Van Kuppeveld FJ, Seipelt J. Antiviral activity of the zinc ionophores pyrithione and hinokitiol against picornavirus infections. J Virol. 2009;83:58–64. doi: 10.1128/JVI.01543-08. [PMC free article] [PubMed] [CrossRef] [Google Scholar].</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Krenn BM, Gaudernak E, Holzer B, Lanke K, Van Kuppeveld FJ, Seipelt J. Antiviral activity of the zinc ionophores pyrithione and hinokitiol against picornavirus infections. J Virol. 2009;83:58–64. doi: 10.1128/JVI.01543-08. [PMC free article] [PubMed] [CrossRef] [Google Scholar].</mixed-citation><mixed-citation xml:lang="en">Lanke K, Krenn BM, Melchers WJ, Seipelt J, van Kuppeveld FJ. PDTC inhibits picornavirus polyprotein processing and RNA replication by transporting zinc ions into cells. J Gen Virol. 2007;88:1206–1217. doi: 10.1099/vir.0.82634-0. [PubMed] [CrossRef] [Google Scholar].</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Lanke K, Krenn BM, Melchers WJ, Seipelt J, van Kuppeveld FJ. PDTC inhibits picornavirus polyprotein processing and RNA replication by transporting zinc ions into cells. J Gen Virol. 2007;88:1206–1217. doi: 10.1099/vir.0.82634-0. [PubMed] [CrossRef] [Google Scholar].</mixed-citation><mixed-citation xml:lang="en">Geist FC, Bateman JA, Hayden FG. In vitro activity of zinc salts against human rhinoviruses. Antimicrob Agents Chemother. 1987; 31:622–624. doi: 10.1128/AAC.31.4.622. [PMC free article][PubMed] [CrossRef] [Google Scholar].</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Geist FC, Bateman JA, Hayden FG. In vitro activity of zinc salts against human rhinoviruses. Antimicrob Agents Chemother. 1987; 31:622–624. doi: 10.1128/AAC.31.4.622. [PMC free article][PubMed] [CrossRef] [Google Scholar].</mixed-citation><mixed-citation xml:lang="en">Hung M, Gibbs CS, Tsiang M. Biochemical characterization of rhinovirus RNA-dependent RNA polymerase. Antiviral Res. 2002;56:99–114. doi: 10.1016/S0166-3542(02)00101-8. [PubMed] [CrossRef] [Google Scholar].</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Hung M, Gibbs CS, Tsiang M. Biochemical characterization of rhinovirus RNA-dependent RNA polymerase. Antiviral Res. 2002;56:99–114. doi: 10.1016/S0166-3542(02)00101-8. [PubMed] [CrossRef] [Google Scholar].</mixed-citation><mixed-citation xml:lang="en">Krenn BM, Holzer B, Gaudernak E, Triendl A, van Kuppeveld FJ, Seipelt J. Inhibition of polyprotein processing and RNA replication of human rhinovirus by pyrrolidine dithiocarbamate involves metal ions. J Virol. 2005;79:13892–13899. doi: 10.1128/JVI.79.22.13892-13899.2005. [PMC free article] [PubMed] [CrossRef] [Google Scholar].</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Krenn BM, Holzer B, Gaudernak E, Triendl A, van Kuppeveld FJ, Seipelt J. Inhibition of polyprotein processing and RNA replication of human rhinovirus by pyrrolidine dithiocarbamate involves metal ions. J Virol. 2005;79:13892–13899. doi: 10.1128/JVI.79.22.13892-13899.2005. [PMC free article] [PubMed] [CrossRef] [Google Scholar].</mixed-citation><mixed-citation xml:lang="en">Suara RO, Crowe JE. Effect of zinc salts on respiratory syncytial virus replication. Antimicrob Agents Chemother. 2004; 48:783–790. doi: 10.1128/AAC.48.3.783-790.2004. [PMC free article] [PubMed] [CrossRef] [Google Scholar].</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Suara RO, Crowe JE. Effect of zinc salts on respiratory syncytial virus replication. Antimicrob Agents Chemother. 2004; 48:783–790. doi: 10.1128/AAC.48.3.783-790.2004. [PMC free article] [PubMed] [CrossRef] [Google Scholar].</mixed-citation><mixed-citation xml:lang="en">Srivastava V, Rawall S, Vijayan VK, Khanna M. Influenza a virus induced apoptosis: Inhibition of DNA laddering &amp; caspase-3 activity by zinc supplementation in cultured HeLa cells. Indian J Med Res. 2009;129:579–586. [PubMed] [Google Scholar].</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Srivastava V, Rawall S, Vijayan VK, Khanna M. Influenza a virus induced apoptosis: Inhibition of DNA laddering &amp; caspase-3 activity by zinc supplementation in cultured HeLa cells. Indian J Med Res. 2009;129:579–586. [PubMed] [Google Scholar].</mixed-citation><mixed-citation xml:lang="en">Ghaffari H, Tavakoli A, Moradi A, Tabarraei A, Bokharaei-Salim F, Zahmatkeshan M, Farahmand M, Javanmard D, Kiani SJ, Esghaei M, et al. Inhibition of H1N1 influenza virus infection by zinc oxide nanoparticles: Another emerging application of nanomedicine. J Biomed Sci. 2019;26:70. doi: 10.1186/s12929-019-0563-4.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Ghaffari H, Tavakoli A, Moradi A, Tabarraei A, Bokharaei-Salim F, Zahmatkeshan M, Farahmand M, Javanmard D, Kiani SJ, Esghaei M, et al. Inhibition of H1N1 influenza virus infection by zinc oxide nanoparticles: Another emerging application of nanomedicine. J Biomed Sci. 2019;26:70. doi: 10.1186/s12929-019-0563-4.</mixed-citation><mixed-citation xml:lang="en">te Velthuis AJ, van den Worm SH, Sims AC, Baric RS, Snijder EJ, van Hemert MJ. Zn(2+) inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture. PLoS Pathog. (2010) 6:e1001176. doi: 10.1371/journal.ppat.1001176.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">te Velthuis AJ, van den Worm SH, Sims AC, Baric RS, Snijder EJ, van Hemert MJ. Zn(2+) inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture. PLoS Pathog. (2010) 6:e1001176. doi: 10.1371/journal.ppat.1001176.</mixed-citation><mixed-citation xml:lang="en">Lian H, Zang R, Wei J, Ye W, Hu MM, Chen YD, et al. The zinc-finger protein ZCCHC3 binds RNA and facilitates viral RNA sensing and activation of the RIG-I-like receptors. Immunity. (2018) 49:438–48.e5. doi: 10.1016/j.immuni.2018.08.014.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Lian H, Zang R, Wei J, Ye W, Hu MM, Chen YD, et al. The zinc-finger protein ZCCHC3 binds RNA and facilitates viral RNA sensing and activation of the RIG-I-like receptors. Immunity. (2018) 49:438–48.e5. doi: 10.1016/j.immuni.2018.08.014.</mixed-citation><mixed-citation xml:lang="en">Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell. (2006) 124:783–801. doi: 10.1016/j.cell.2006.02.015.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell. (2006) 124:783–801. doi: 10.1016/j.cell.2006.02.015.</mixed-citation><mixed-citation xml:lang="en">Gammoh NZ, Rink L. Zinc in infection and inflammation. Nutrients. (2017) 9:624. doi: 10.3390/nu9060624.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Gammoh NZ, Rink L. Zinc in infection and inflammation. Nutrients. (2017) 9:624. doi: 10.3390/nu9060624.</mixed-citation><mixed-citation xml:lang="en">Trudnyi patsient 2010 god tsink i zhelezo - 12 Brooks W.A., Santosham M., Naheed A., Goswami D., Wahed M.A., Diener-West M., Faruque A.S., Black R.E. Effect of weekly zinc supplements on incidence of pneumonia and diarrhoea in children younger than 2 years in an urban, low-income population in Bangladesh: randomised controlled trial // Lancet. 2005; 366: 9490: 999-1004.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Brooks W.A., Santosham M., Naheed A., Goswami D., Wahed M.A., Diener-West M., Faruque A.S., Black R.E. Effect of weekly zinc supplements on incidence of pneumonia and diarrhoea in children younger than 2 years in an urban, low-income population in Bangladesh: randomised controlled trial // Lancet. 2005; 366: 9490: 999-1004.</mixed-citation><mixed-citation xml:lang="en">Amit Kumar, Yuichi Kubota, Mikhail Chernov, and Hidetoshi Kasuyac Potential role of zinc supplementation in prophylaxis and treatment of COVID-19 Med Hypotheses. 2020 Nov; 144: 109848. Published online 2020 May 25. doi: 10.1016/j.mehy.2020.109848 PMCID: PMC7247509 PMID: 32512490.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Amit Kumar, Yuichi Kubota, Mikhail Chernov, and Hidetoshi Kasuyac Potential role of zinc supplementation in prophylaxis and treatment of COVID-19 Med Hypotheses. 2020 Nov; 144: 109848. Published online 2020 May 25. doi: 10.1016/j.mehy.2020.109848 PMCID: PMC7247509 PMID: 32512490.</mixed-citation><mixed-citation xml:lang="en">Amit Kumar, Yuichi Kubota, Mikhail Chernov, and Hidetoshi Kasuyac Potential role of zinc supplementation in prophylaxis and treatment of COVID-19 Med Hypotheses. 2020 Nov; 144: 109848. Published online 2020 May 25. doi: 10.1016/j.mehy.2020.109848 PMCID: PMC7247509 PMID: 32512490.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
