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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">alternative</journal-id><journal-title-group><journal-title xml:lang="ru">Альтернативная энергетика и экология (ISJAEE)</journal-title><trans-title-group xml:lang="en"><trans-title>Alternative Energy and Ecology (ISJAEE)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1608-8298</issn><publisher><publisher-name>Международный издательский дом научной периодики "Спейс</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15518/isjaee.2024.06.103-111</article-id><article-id custom-type="elpub" pub-id-type="custom">alternative-2434</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>V.  КОНСТРУКЦИОННЫЕ МАТЕРИАЛЫ. 13. Наноструктуры</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>V.  STRUCTURAL MATERIALS. 13. Nanostructures</subject></subj-group></article-categories><title-group><article-title>Композитное коррозионностойкое биоактивное покрытие для Ni-Ti сплавов</article-title><trans-title-group xml:lang="en"><trans-title>Composite corrosion-resistant bioactive coating for Ni-Ti alloys</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4615-5270</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Марченко</surname><given-names>Е. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Marchenko</surname><given-names>E. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Марченко Екатерина Сергеевна – доцент, доктор физ.-мат. наук.</p><p>634050, Томск, пр. Ленина, 36</p></bio><bio xml:lang="en"><p>Marchenko Ekaterina S. - Associate Professor, Doctor of Physics and Mathematics. Sci.</p><p>634050, Tomsk, Lenina Ave. 36</p></bio><email xlink:type="simple">89138641814@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9853-2766</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Байгонакова</surname><given-names>Г. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Baigonakova</surname><given-names>G. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Байгонакова Гульшарат Аманболдыновна - старший научный сотрудник, канд. физ.-мат. наук.</p><p>634050, Томск, пр. Ленина, 36</p></bio><bio xml:lang="en"><p>Baigonakova Gulsharat A. - senior researcher, Ph.D. physics and mathematics Sci.</p><p>634050, Tomsk, Lenina Ave. 36</p></bio><email xlink:type="simple">gat27@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0823-7208</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дубовиков</surname><given-names>К. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Dubovikov</surname><given-names>K. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дубовиков Кирилл Максимович - аспирант, младший научный сотрудник.</p><p>634050, Томск, пр. Ленина, 36</p></bio><bio xml:lang="en"><p>Dubovikov Kirill M. - graduate student, junior researcher</p><p>634050, Tomsk, Lenina Ave. 36</p></bio><email xlink:type="simple">kirill_dubovikov@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5674-0177</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Топольницкий</surname><given-names>Е. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Topolnitskiy</surname><given-names>E. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Топольницкий Евгений Богданович - врач – торакальный хирург высшей категории, врач-хирург высшей категории, доцент, доктор мед. наук.</p><p>634050, Томск, Московский тракт, 2</p></bio><bio xml:lang="en"><p>Topolnitskiy Evgeniy B. - thoracic surgeon of the highest category, surgeon of the highest category, associate professor, Doctor of Science. honey. Sci.</p><p>634050, Tomsk, Moskovsky Trakt, 2</p></bio><email xlink:type="simple">e_topolnitskiy@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Национальный исследовательский Томский государственный университет Россия</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Research Tomsk State University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Сибирский государственный медицинский университет Россия</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Siberian State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>13</day><month>06</month><year>2024</year></pub-date><volume>0</volume><issue>6</issue><fpage>103</fpage><lpage>111</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Международный издательский дом научной периодики "Спейс, 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Международный издательский дом научной периодики "Спейс</copyright-holder><copyright-holder xml:lang="en">Международный издательский дом научной периодики "Спейс</copyright-holder><license xlink:href="https://www.isjaee.com/jour/about/submissions#copyrightNotice" xlink:type="simple"><license-p>https://www.isjaee.com/jour/about/submissions#copyrightNotice</license-p></license></permissions><self-uri xlink:href="https://www.isjaee.com/jour/article/view/2434">https://www.isjaee.com/jour/article/view/2434</self-uri><abstract><p>Использование NiTi в качестве материала для имплантатов возможно, благодаря его биоинертности. Но при этом необходимо обеспечить ему, во-первых, дополнительную защиту, так как при взаимодействии с живыми тканями NiTi подвергается коррозии, а во-вторых, усилить биоактивность поверхности, чтобы ускорить регенерацию поврежденной ткани. Поэтому для решения данной задачи было изготовлено методами магнетронного и плазменно-ассистированного ВЧ-распыления двуслойное покрытие, одна часть которого препятствует коррозии, а вторая повышает биоактивность. Установлено, что сформировавшееся кальций-фосфатное покрытие имеет плотную и беспоровую структуры, а само покрытие включает в себя элементы кальция, фосфора и кислорода. Данные об элементном составе хорошо коррелируют с данными рентгеноструктурного анализа дифракции, согласно которому покрытие состоит из гидроксиапатита гексагональной сингонии. MTT-тест, проведенный с группами образцов без и с кальций-фосфатным покрытием показал, что процент умерших клеток составляет 11 ± 4% и 12 ± 3% соответственно. Предварительное in vitro исследование свидетельствует в пользу остеогенной активности образцов с покрытием. Полученные результаты показывают, что в перспективе данные материалы могут быть использованы для изготовления костных имплантатов, так как сформировавшийся гидроксиапатит имеет наибольшую схожесть с биологическим. При этом необходимо в дальнейшем расширить исследования остеогенеза на данных покрытиях, чтобы убедиться в способности положительно влиять на процесс образования костной ткани.</p></abstract><trans-abstract xml:lang="en"><p>The use of NiTi as a material for implants is possible due to its bioinertness. But at the same time, it is necessary to provide it, firstly, with additional protection, since when interacting with living tissues, NiTi undergoes corrosion, and secondly, to enhance the bioactivity of the surface in order to accelerate the regeneration of damaged tissue. Therefore, to solve this problem, a two-layer coating was produced using magnetron and plasma-assisted RF sputtering, one part of which prevents corrosion, and the second increases bioactivity. It has been established that the formed calcium phosphate coating has a dense and pore-free structure, and the coating itself includes elements of calcium, phosphorus and oxygen. Data on the elemental composition correlate well with the data of X-ray diffraction analysis, according to which the coating consists of hydroxyapatite of the hexagonal system. The MTT test conducted with groups of samples without and with calcium phosphate coating showed that the percentage of dead cells was 11 ± 4% and 12 ± 3%, respectively. Preliminary in vitro studies support the osteogenic activity of the coated samples. The results obtained show that in the future these materials can be used for the manufacture of bone implants, since the formed hydroxyapatite is most similar to biological one. At the same time, it is necessary to further expand studies of osteogenesis on these coatings to ensure their ability to positively influence the process of bone tissue formation.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>сплав NiTi</kwd><kwd>гидроксиапатит</kwd><kwd>нитрид титана</kwd><kwd>напыление</kwd><kwd>биосовместимость</kwd></kwd-group><kwd-group xml:lang="en"><kwd>NiTi alloy</kwd><kwd>hydroxyapatite</kwd><kwd>titanium nitride</kwd><kwd>sputtering</kwd><kwd>biocompatibility</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование выполнено за счет гранта Российского Научного Фонда (РНФ), No 19-72-10105, https://rscf.ru/project/19-72-10105/</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Hench L. L. Bioceramics: From concept to clinic. J. Am. Ceram. Soc. 1991; 74:1487–1510. 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