D.Sc. in Chemistry, Head of the Labora tory, Siberian Physical-Technical Insti tute of Tomsk State University

The article considers and analyzes an important stage in the development of laser systems for metal vapor from the point of view of biomedical applications. Since the advent of the first generation of domestic medical facilities with pulsed lasers on metal vapors, in particular, copper vapors (LSM), which were created in the FSUE “Research and Production Enterprise ‘Istok’”, not much time has passed. Now similar studies are widely developed and include a variety of uses, for instance, in oncology for treatment with photodynamic therapy (PDT), angioplasty of intravascular destruction of atherosclerotic lesions, dermatology and cosmetology for the treatment of facial skin defects, as well as otorhinolaryngology, gynecology, proctology, urology, and others. In that cases, doctors use the Yantar-2Fand Yakhroma-2 installations, developed on the basis of the “Kurs” LPM with radiation wavelengths λ = 510.6 nm and 578 nm and the average radiation power P_rad = 5–10 W and tunable in wavelengths in the range of λ = 620–670 nm. Laser radiation is delivered to the affected area of a bio-object using a flexible light-guide cable with a diameter of 400, 600 or 800 μm fiber, which is one of the most convenient medical instruments. A compact and air-cooled medical installation of the new generation “Yakhroma-Med” based on the pulsed LPM “Kulon” with an average radiation power at the output of the light-guide cable P_rad = 1–3 W uses in dermatology and cosmetology (together with the Lebedev Physics Institute of the Russian Academy of Sciences). Today, YakhromaMed is the leader in non-ablative technologies and is optimal for removing vascular, pigmented and unstained skin defects, treating acne and smoothing wrinkles. It is used in more than 100 clinics in Russia and abroad. Moreover, for scientific and practical medicine in the field of oncology, low-intensity laser therapy and surgery, dermatology and cosmetology, etc., a compact air-cooled industrial multifunctional high-intensity medical unit “Kulon-Med” (similar to Yakhroma-Med) based on two pulsed lasers was developed: LM “Kulon” with an average radiation power P_rad = 10 W and LVRK with radiation tunable in wavelengths in the range λ = 620–750 nm and radiation power P_rad = 1–3 W (together with Ltd. NPP VELIT, Kurchatov Institute and the Hertzen Hermitage Research and Development Institute). The laser radiation is transported using four flexible light-guide cables with a conductive quartz fiber diameter of 400 and 600 μm, which makes it possible to perform a therapeutic and prophylactic procedure simultaneously in several rooms. Medical facilities of this class have been put in many medical institutions.
This report on the use of CVL in medicine says only about the developments in theMoscow region.

1. A.G. Grigorian, M.A. Kazaryan, N.A. Lyabin. Copper vapor lasers (Laseri na parakh metalov). Fizmatlit, 2005; 312 p. (in Russ.).

2. Asratyan A.A., Bulychev N.A., Feofanov I.N., Kazaryan M.A., Krasovskii V.I., Lyabin N.A., Pogosyan L.A., Sachkov V.I., Zakharyan R.A. Laser processing with specially designed laser beam. Applied Physics A, 2016;122–128:434.

3. Asratyan A.A., Solovyev D.V., Smirnova O.A., Kazaryan S.M., Rusakova E.V. Parenteral viral hepatitis and tuberculosis: current problems of epidemiology and prevention (Parenteral'nyye virusnyye gepatity i tuberkulez: sovremennyye problemy epidemiologii i profilaktiki). Epidemiology and infectious diseases. Epidemiologiya i infektsionnyye bolezni, 2017;3:9–15 (in Russ.).

4. Asratyan A.A., Simonov E.G., Ghazaryan S.M., Orlova O.A., Ilenkina K.V., Sipacheva N.B., Karazhas N.V., Račić S.R. Epstein-Barr Viral Infection: Current Situation and Clinical and Epidemiological Features in Women of Childbearing Age and Newborns (EpshteynBarr virusnaya infektsiya: sovremennaya situatsiya i kliniko-epidemiologicheskiye osobennosti u zhenshchin detorodnogo vozrasta i novorozhdennykh), ZhMEI;ID:25–32 (in Russ.).

5. Lyabin N.А., Chursin A.D., Ugolnikov S.A., Koroleva M.E., Kazaryan M.A. Development, production and use of sealed copper and gold vapor lasers / Razrabotka, proizvodstvo i primeneniye otpayannykh lazerov na parakh medi i zolota. Quant. electronic, 2001;31(3):191–202 (in Russ.).

6. Aleinikov V.S., Belyaev V.P., Devyatkov N.D. Lazep na papakh medi – istochnik izlucheniya dlya mnogofunktsional'noy meditsinskoy appapatupy v biomeditsinskikh issledovaniyakh (Copper vapor laser - radiation source for multifunctional medical equipment in biomedical research). Electronic industry, 1984;(10):10–12 (in Russ.).

7. Armichev A.V., Aleinikov V.S., Masychev V.I. Laser medical installation with wavelength of radiation (Lazepnaya meditsinskaya ustanovka s pepestpaivayemoy dlinoy volny izlucheniya). Electronic Industry, 1984;(10):29–31 (in Russ.).

8. Aleinikov V.S., Masychev V.I. Study of the possibility of applying radiation on copper pairs in laser surgical facilities (Issledovaniye vozmozhnosti ppimeneniya izlucheniya na papakh medi v lazepnykh khipupgicheskikh utsanovkakh). Electronic industry, 1984;(10):32–35 (in Russ.).

9. Devyatkov N.D., Rabkin I.Kh., Maksimovich I.V., Horn K.A., Aleinikov V.S., Lyabin N.A., Mamedli L.D., Masychev V.I. Application of copper vapor laser for vaporization of atherosclerotic effects of in vitro mag- nal arteries (Ppimeneniye izlucheniya lazepa na papakh medi dlya ispapeniya ateposklepoticheskikh popazheniy magistpal'nykh aptepiy in vitro). Surgery, 1986;(4):116–121 (in Russ.).

10. Lasers Use in Oncology: CIS Selected Papers / Ed. Аndrey.V. Ivanov & M..A.Kazaryan. Proc.SPIE, 1996, no. 2728.

11. Ponomarev I.V. The use of metal vapor lasers in medicine (Ppimeneniye lazepov na papakh metallov v meditsine). Moscow: Physical Institute im.PNN. Lebedeva RAN Publ., 1997; 56 p. (in Russ.).

12. Ponomarev I.V. Laser surgery for vascular and pigmented skin defects (Lazernaya khirurgiya sosudistykh i pigmentnykh defektov kozhi). Moscow: Physical Institute im.PNN. Lebedeva, Russian Academy of Sciences, 2001; 48 p. (in Russ.).

13. Treatment of epithelial formations of the skin with a laser medical device on Yakhroma-Med copper. Lecheniye epitelial'nykh obrazovaniy kozhi lazernym meditsinskim apparatom na parakh medi “YakhromaMed” / Methodical recommendations. SPb: SPbGMA them. Mechnikova Publ., 2004; 52 p. (in Russ.).

14. Klyuchareva S.V., Ponomarev I.V., Selivanova OD Treatment of skin neoplasms in the periorbital region with non-ablative methods (Lecheniye novoobrazovaniy kozhi v periorbital'noy oblasti neablyatsinnymi metodami). Experimental and clinical dermatocosmitology, 2008;(6):50–55 (in Russ.).

15. Lepekhin N.М., Priseko Yu.S., Filippov V.G., Lyabin N.A., Chursin A.D.Industrial metal vapor lasers for scientific medicine and practical health protection (Promyshlennyye lazery na parakh metallov dlya nauchnoy meditsiny i prakticheskogo zdravokhroneniya). Laser medicine, 2004;8(3):186 (in Russ.).

16. Sokolov V.V., Chissov V.I., Lepekhin N.M., Priseko Yu.S., Filippov V.G., Lyabin N.A., Chursin A.D., Firsov V.A., Dyachkov A.B. Laser medical installation of the new generation “Kulon-Med” for scientific and practical medicine (Lazernaya meditsinskaya ustanovka novogo pokoleniya «Kulon-Med» dlya nauchnoy i prakticheskoy meditsiny). Materials of the scientific-practical conference “Modern achievements of laser medicine and their application in practical healthcare”, October 5–6, 2006, Moscow; pp. 200–201(in Russ.).

17. Photodynamic Therapy: Materials of the III AllRussian Symposium (Fotodinamicheskaya tepapiya: Matepialy III Vsepossiyskogo simpoziuma). 11–12 October 1999, Moscow: GNTsLM, 1999; 208 p. (in Russ.).

18. Stranadko E.F., Markkichev NA, Ryabov M.V. Photodynamic therapy in the treatment of malignant neoplasms of various sites: Fotodinamicheskaya terapiya v lechenii zlokachestvennykh novoobpazovaniy razlichnykh lokalizatsiy. A manual for doctors. Moscow: GNTsLM, 1999; 19 p. (in Russ.).

19. Evtushenko V.A., Zyryanov B.N., Soldatov A.N. Laser therapy of oncological patients (Lazepotepapiya onkologicheskikh bol'nykh). Izv. universities. Physics, 1999;42(8):109–118. The parameters of the radiation of an industrial laser “KULON-10 CUM” in the mode of high-speed pulse modulation / N.M. Lepekhin, Yu.S. Priseko, V.G. Phillipov, M.M. Malikov, V.T. Korpukhin, N.A. Lyabin, A.D. Chursin // Lasers in science engineering and medicine: Collection of scientific works / Ed. V. Petrova. Moscow: MNTORES them. A.S. Popova, 2007; pp. 39–42 (in Russ.).

20. Chissov V.I., Sokolov V.V., Lepekhin N.M., Priseko Yu.S., Filippov V.G., Galletov M.V., Khrapov A.V. Multifunctional laser medical installation “KulonMed” for scientific and practical medicine (Mnogofunktsional'naya lazernaya meditsinskaya ustanovka «Kulon-Med» dlya nauchnoy i prakticheskoy meditsiny). Laser medicine, 2011;15(4):40–47 (in Russ.).

21. Vasiliev N.E., Romanov V.N. pH of the intraorgan environment, as one of the parameters for photodynamic therapy (pH vnutriorgannoy sredy, kak odin iz parametrov dlya fotodinamicheskoy terapii). Laser Medicine, 2002;6(1):30–32 (in Russ.).

22. Lepekhin N.М., Priseko Yu.S., Lyabin N.A., Chursin A.D.Pulse regulation of the radiation of an industrial metal vapor laser of the “Kulon” series (Impul'snoye regulirovaniye izlucheniya promyshlennogo lazera na parakh metallov serii «Kulon»). Lasers in science, technology, medicine: Collection of scientific papers / Ed. V.A. Petrova. Moscow: MNTORES them. A.S. Popova, 2003; pp. 72–74 (in Russ.).

23. Lepekhin N.M., Priseko Yu.S., Filippov V.G. Pulse submodulator of the power source of industrial copper vapor lasers // Lasers in science, technology, medicine: (Impul'snyy podmodulyator istochnika pitaniya promyshlennykh lazerov na parakh medi). Collection of scientific papers / Ed. V.A. Petrova. Moscow: MNTORES them. A.S. Popova, 2004; pp. 18–20 (in Russ.).

24. Lepekhin N.М., Priseko Yu.S., Lyabin N.A., Filippov V.G., Chursin A.D. Industrial metal vapor lasers. Promyshlennyye lazery na parakh metallov // Lasers in science engineering and medicine: Collection of scientific works / Ed. V.Petrova. Moscow: MNTORES them. A.S. Popova, 2004; pp. 20–23 (in Russ.).

25. Lepekhin N.M., Priseko Yu.S., Filippov V.G. The device for regulating the voltage on the capacitive storage of the generator of nanosecond pulses. Ustroystvo regulirovaniya napryazheniya na yemkostnom nakopitele generatora nanosekundnykh impul'sov// Lasers in science, technology, medicine: Collection of scientific works / Ed. V.A. Petrova. Moscow: MNTORES them. A.S. Popova, 2004; pp. 23–25 (in Russ.).

26. Lepekhin N.М., Priseko Yu.S., Filippov V.G., Lyabin N.A. Development of a power source for lasers on self-limited transitions of metal atoms with Qswitching (Razrabotka istochnika pitaniya lazerov na samoogranichennykh perekhodakh atomov metallov s modulyatsiyey dobrotnosti). Electrical Engineering 2010: Proc. report VIII simp. Moscow, VEI, May 24–26, 2005; p. 153 (in Russ.).

27. Lepekhin N.M., Priseko Yu.S., Purseev N.I. Laser copper vapor series “Pendant” for precision processing of thin sheet materials (Lazer na parakh medi serii «KULON» dlya pretsizionnoy obrabotki tonkikh listovykh materialov/). Electrical Engineering 2030: Tez. report IX Symp. Moscow, VEI, May 29–31, 2007; p. 277 (in Russ.).

28. Lepekhin N.M., Priseko Yu.S., Filippov V.G., Lyabin N.A., Chursin A.D. High-speed pulse modulation of laser radiation on self-limited transitions of metal atoms (Vysokoskorostnaya impul'snaya modulyatsiya izlucheniya lazerov na samoogranichennykh perekhodakh atomov metallov). Metal vapor lasers: Proc. report simp Loo, September 21–23, 2004; p. 50 (in Russ.).

29. Lepekhin N.M., Priseko Yu.S., Filippov V.G., Lyabin N.A., Chursin A.D., Paramonov V.S., Kazaryan M.A. Device and characteristics of an industrial sealed KULON-15CU copper vapor laser (Ustroystvo i kharakteristiki promyshlennogo otpayannogo lazera na parakh medi KULON-15CU). Metal vapor lasers: Proc. report simp Loo, September 21–23, 2004; p. 51 (in Russ.).

30. Soldiers A.N., Yermolaev AP., Voronov V.I., Sukhanov V.B., Reimer I.V., Shumeyko A.S., Lyabin N.A., Evtushenko V.A., Filippov V.G., Pritseko Yu.S. Laser medical complex for the treatment of cancer and skin diseases (Lazernyy meditsinskiy kompleks dlya lecheniya onkologicheskikh i kozhnykh zabolevaniy). Metal vapor lasers: Proc. report simp Loo, September 21–23, 2004; p. 88 (in Russ.).

31. Lepekhin N.M., Priseko Yu.S., Filippov V.G., Malikov M.M., Karpukhin V.T., Lyabin N.A., Chursin A.D.Study of the energy characteristics of an industrial laser series "KULON" .Issledovaniye energeticheskikh kharakteristik promyshlennogo lazera serii «KULON». Metal vapor lasers: Proc. report simp Loo, September 25–29, 2006; p. 7 (in Russ.).

32. Lyabin N.A., Chursin A.D., Phillipov V.G., Priseko Yu.S., Lepekhin N.M., Firsov V.A., Dyachkov A.D., Sokolov V.V. Laser medical device of the new generation “Kulon-M” for PDT (Lazernaya meditsinskaya ustanovka novogo pokoleniya «Kulon-M» dlya FDT). Lasers in science engineering and medicine: Collection of scientific works / Ed. V.Petrova. Moscow: MNTORES them. A.S. Popova, 2005; pp. 98–105 (in Russ.).

33. Lepekhin N.M., Priseko Yu.S., Fillipov V.G., Sokolov V.V., Chissov V.I., Lyabin N.A., Cursin A.D., Firsov V.A., Dyachkov A.D. Laser medical installation “Coulon-Med” for photodynamic therapy (Lazernaya meditsinskaya ustanovka «Kulon-Med» dlya fotodinamicheskoy terapii). Lasers in Science, Engineering and Medicine: Collection of Scientific Works / Ed. V.Petrova. Moscow: MNTORES them. A.S. Popova, 2006; P. 92–95 (in Russ.).

34. Grigoryants A.G., Kazaryan M.A., Lyabin N.A. Laser precision micromachining of materials (Lazernaya pretsizionnaya mikroobrabotka materialov). Moscow: Fizmatlit, 2017; 414 p. (in Russ.)